HAS1 anticorps (AA 166-193)

N° du produit ABIN3031258

Cet anticorps Lapin Polyclonal détecte spécifiquement HAS1 dans WB et ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour HAS1 anticorps (AA 166-193) (ABIN3031258)

Antigène: HAS1 (Hyaluronan Synthase 1 (HAS1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HAS1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-HAS1 anticorps

Épitope: AA 166-193

Réactivité croisée (Details): Expected species reactivity: Mouse

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 166-193 from the human protein was used as the immunogen for this HAS1 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the HAS1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the HAS1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur HAS1

Antigène: HAS1 (Hyaluronan Synthase 1 (HAS1))

Autre désignation: HAS1

Sujet: Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase.

UniProt: Q92839

Pathways: Glycosaminoglycan Metabolic Process