IRF3 anticorps (AA 46-72)

N° du produit ABIN3031417

Cet anticorps Lapin Polyclonal détecte spécifiquement IRF3 dans WB et ELISA. Il présente une réactivité envers Souris.

Aperçu rapide pour IRF3 anticorps (AA 46-72) (ABIN3031417)

Antigène: IRF3 (Interferon Regulatory Factor 3 (IRF3))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IRF3 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-IRF3 anticorps

Épitope: AA 46-72

Réactivité croisée (Details): Expected species reactivity: Bovine, Pig

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 46-72 from the mouse protein was used as the immunogen for this Irf3 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the Irf3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Irf3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur IRF3

Antigène: IRF3 (Interferon Regulatory Factor 3 (IRF3))

Autre désignation: Irf3

Sujet: Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains (By similarity).

UniProt: P70671

Pathways: Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades