JMJD2D anticorps (AA 484-516)

N° du produit ABIN3031654

Cet anticorps Lapin Polyclonal détecte spécifiquement JMJD2D dans ELISA et WB. Il présente une réactivité envers Humain.

Aperçu rapide pour JMJD2D anticorps (AA 484-516) (ABIN3031654)

Antigène: JMJD2D (KDM4D) (Lysine (K)-Specific Demethylase 4D (KDM4D))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp JMJD2D est non-conjugé

Application: ELISA, Western Blotting (WB)

Détail du produit anti-JMJD2D anticorps

Épitope: AA 484-516

Purification: Purified

Immunogène: A portion of amino acids 484-516 from the human protein was used as the immunogen for this JMJD2D antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the JMJD2D antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the JMJD2D antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur JMJD2D

Antigène: JMJD2D (KDM4D) (Lysine (K)-Specific Demethylase 4D (KDM4D))

Autre désignation: JMJD2D (KDM4D)

Sujet: Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.

UniProt: Q6B0I6

Pathways: L'effet Warburg