MERTK anticorps (C-Term)

N° du produit ABIN3030226

Cet anticorps Lapin Polyclonal détecte spécifiquement MERTK dans WB et ELISA. Il présente une réactivité envers Souris et Rat.

Aperçu rapide pour MERTK anticorps (C-Term) (ABIN3030226)

Antigène: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MERTK est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-MERTK anticorps

Épitope: C-Term

Purification: Antigen affinity purified

Immunogène: This Mertk antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 946-980 amino acids from the C-terminal region of mouse Mertk.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the Mertk antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000-2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Mertk antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur MERTK

Antigène: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Autre désignation: Mertk

Sujet: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll- like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

UniProt: Q60805

Pathways: Signalisation RTK