MYLK anticorps (AA 908-938)

N° du produit ABIN3031918

Détail du produit anti-MYLK anticorps

Antigène: MYLK (Myosin Light Chain Kinase (MYLK))

Épitope: AA 908-938

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MYLK est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée (Details): Expected species reactivity: Rabbit

Purification: Purified

Immunogène: A portion of amino acids 908-938 from the human protein was used as the immunogen for this MLCK antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the MLCK antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. IHC (Paraffin): 1:50-1:100,Western blot: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the MLCK antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur MYLK

Antigène: MYLK (Myosin Light Chain Kinase (MYLK))

Autre désignation: MLCK (MYLK Produits)

Synonymes: anticorps AAT7, anticorps KRP, anticorps MLCK, anticorps MLCK1, anticorps MLCK108, anticorps MLCK210, anticorps MSTP083, anticorps MYLK1, anticorps smMLCK, anticorps 9530072E15Rik, anticorps A930019C19Rik, anticorps AW489456, anticorps Mlck, anticorps SMMLCK, anticorps mlck, anticorps fj60a06, anticorps mlck1a, anticorps mylk, anticorps wu:fj60a06, anticorps zmlck1, anticorps myosin light chain kinase, anticorps myosin, light polypeptide kinase, anticorps myosin, light chain kinase a, anticorps MYLK, anticorps Mylk, anticorps mylka

Sujet: MLCK, a member of the Ser/Thr protein kinase family, is a calcium/calmodulin-dependent enzyme responsible for smooth muscle contraction via phosphorylation of a specific serine in the N-terminus of myosin light chains (MLC), an event that facilitates myosin interaction with actin filaments. It is a central determinant in the development of vascular permeability and tissue edema formation. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. MLCK acts as a critical participant in signaling sequences that result in fibroblast apoptosis. Smooth muscle and non-muscle isozymes are expressed in a wide variety of adult and fetal tissues and in cultured endothelium with qualitative expression appearing to be neither tissue- nor development-specific. Non-muscle isoform 2 is the dominant splice variant expressed in various tissues. The Telokin isoform, which binds calmodulin, has been found in a wide variety of adult and fetal tissues. MLCK is probably down-regulated by phosphorylation. The protein contains 1 fibronectin type III domain and 9 immunoglobulin-like C2-type domains.

UniProt: Q15746