PML anticorps (Sumoylation Site)

N° du produit ABIN3032330

L’anticorps Lapin Polyclonal anti-PML a été validé pour WB, IHC, IF, ELISA et FACS. Il convient pour détecter PML dans des échantillons de Humain.

Aperçu rapide pour PML anticorps (Sumoylation Site) (ABIN3032330)

Antigène: PML (Promyelocytic Leukemia (PML))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PML est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA, Flow Cytometry (FACS)

Détail du produit anti-PML anticorps

Épitope: AA 470-499, Sumoylation Site

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 470-499 (sumoylation site) from the human protein was used as the immunogen for this PML antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the PML antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100,Immunofluorescence: 1:10-1:50,Flow Cytometry: 1:10-1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the PML antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur PML

Antigène: PML (Promyelocytic Leukemia (PML))

Autre désignation: PML

Sujet: PML is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL).

UniProt: P29590

Pathways: Signalisation p53, Retinoic Acid Receptor Signaling Pathway, Maintenance of Protein Location, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus