PUMA anticorps (AA 119-154)

N° du produit ABIN3030112

Cet anticorps Lapin Polyclonal détecte spécifiquement PUMA dans WB, ELISA, IHC, IF et FACS. Il présente une réactivité envers Humain.

Aperçu rapide pour PUMA anticorps (AA 119-154) (ABIN3030112)

Antigène: PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PUMA est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-PUMA anticorps

Épitope: AA 119-154

Réactivité croisée (Details): Expected species reactivity: Mouse, Rat

Purification: Purified

Immunogène: A portion of amino acids 119-154 (BH3 domain) from the human protein was used as the immunogen for this Puma antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the Puma antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50,Immunofluorescence: 1:10-1:50,Flow Cytometry: 1:10-1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Puma antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur PUMA

Antigène: PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))

Autre désignation: Puma

Sujet: PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.

UniProt: Q9BXH1

Pathways: Signalisation p53, Positive Regulation of Endopeptidase Activity