SIRT5 anticorps (AA 263-292)

N° du produit ABIN3032595

Détail du produit anti-SIRT5 anticorps

Antigène: SIRT5 (Sirtuin 5 (SIRT5))

Épitope: AA 263-292

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIRT5 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Purified

Immunogène: A portion of amino acids 263-292 from the human protein was used as the immunogen for this SIRT5 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the SIRT5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. IHC (Paraffin): 1:50-1:100,Western blot: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the SIRT5 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur SIRT5

Antigène: SIRT5 (Sirtuin 5 (SIRT5))

Autre désignation: SIRT5 (SIRT5 Produits)

Synonymes: anticorps SIR2L5, anticorps 0610012J09Rik, anticorps 1500032M05Rik, anticorps AV001953, anticorps zgc:92288, anticorps sirt5-a, anticorps SIRT5, anticorps sir2l5, anticorps sirtuin 5, anticorps sirtuin 5 L homeolog, anticorps SIRT5, anticorps Sirt5, anticorps sirt5, anticorps sirt5.L, anticorps CC1G_00083

Sujet: SIRT5 is an NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity, however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX. [UniProt]

UniProt: Q9NXA8

Pathways: SARS-CoV-2 Protein Interactome