SLUG anticorps (AA 1-30)

N° du produit ABIN3032603

Détail du produit anti-SLUG anticorps

Antigène: SLUG (SNAI2) (Snail Family Zinc Finger 2 (SNAI2))

Épitope: AA 1-30

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLUG est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée (Details): Expected species reactivity: Bovine, Mouse, Rat

Purification: Purified

Immunogène: A portion of amino acids 1-30 from the human protein was used as the immunogen for this SLUG antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the SLUG antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the SLUG antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur SLUG

Antigène: SLUG (SNAI2) (Snail Family Zinc Finger 2 (SNAI2))

Autre désignation: SLUG (SNAI2) (SNAI2 Produits)

Synonymes: anticorps Slug, anticorps Slugh, anticorps Snail2, anticorps snail family transcriptional repressor 2, anticorps snail family zinc finger 2, anticorps Snai2

Sujet: SNAI2/SLUG is a transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and  HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.

UniProt: O43623