SMAD4 anticorps (AA 400-428)

N° du produit ABIN3032608

Cet anticorps Lapin Polyclonal détecte spécifiquement SMAD4 dans WB, IHC, ELISA, IF et FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour SMAD4 anticorps (AA 400-428) (ABIN3032608)

Antigène: SMAD4 (SMAD Family Member 4 (SMAD4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMAD4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-SMAD4 anticorps

Épitope: AA 400-428

Fonction: SMAD4 Antibody

Réactivité croisée (Details): Expected species reactivity: Mouse, Rat, Bovine, Pig

Purification: Purified

Immunogène: A portion of amino acids 400-428 from the human protein was used as the immunogen for this SMAD4 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the SMAD4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Aliquot the SMAD4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur SMAD4

Antigène: SMAD4 (SMAD Family Member 4 (SMAD4))

Autre désignation: SMAD4

Sujet: In muscle physiology, SMAD4 plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By similarity). [UniProt]

UniProt: Q13485

Pathways: Cycle Cellulaire, Chromatin Binding, Autophagy