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SMAD4 anticorps (AA 400-428)

SMAD4 Reactivité: Humain WB, ELISA, IHC, IF, FACS Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN3032608
  • Antigène Voir toutes SMAD4 Anticorps
    SMAD4 (SMAD Family Member 4 (SMAD4))
    Épitope
    • 12
    • 11
    • 10
    • 9
    • 8
    • 7
    • 7
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 400-428
    Reactivité
    • 104
    • 42
    • 37
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 93
    • 11
    • 1
    Lapin
    Clonalité
    • 79
    • 26
    Polyclonal
    Conjugué
    • 58
    • 9
    • 9
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SMAD4 est non-conjugé
    Application
    • 70
    • 45
    • 39
    • 29
    • 22
    • 13
    • 9
    • 8
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)
    Réactivité croisée (Details)
    Expected species reactivity: Mouse, Rat, Bovine, Pig
    Purification
    Purified
    Immunogène
    A portion of amino acids 400-428 from the human protein was used as the immunogen for this SMAD4 antibody.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product SMAD4 Anticorps primaire
  • Indications d'application
    Titration of the SMAD4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50,Immunofluorescence: 1:10-1:50,Flow Cytometry: 1:10-1:50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Aliquot the SMAD4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Antigène
    SMAD4 (SMAD Family Member 4 (SMAD4))
    Autre désignation
    SMAD4 (SMAD4 Produits)
    Synonymes
    anticorps smad4, anticorps DPC4, anticorps JIP, anticorps MADH4, anticorps MYHRS, anticorps AW743858, anticorps D18Wsu70e, anticorps Madh4, anticorps XSmad4alpha, anticorps Xsmad4, anticorps dpc4, anticorps jip, anticorps madh4, anticorps xsmad4a, anticorps SMAD family member 4, anticorps Smad4 protein, anticorps SMAD family member 4, gene 1 L homeolog, anticorps SMAD4, anticorps smad4, anticorps Smad4, anticorps smad4.1.L
    Sujet
    In muscle physiology, SMAD4 plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By similarity). [UniProt]
    UniProt
    Q13485
    Pathways
    Cycle Cellulaire, Chromatin Binding, Autophagy
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