TXN anticorps (AA 1-30)

N° du produit ABIN3029119

Cet anticorps Lapin Polyclonal détecte spécifiquement TXN dans WB et ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour TXN anticorps (AA 1-30) (ABIN3029119)

Antigène: TXN (Thioredoxin (TXN))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TXN est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-TXN anticorps

Épitope: AA 1-30

Purification: Purified

Immunogène: A portion of amino acids 1-30 from the human protein was used as the immunogen for this Thioredoxin antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the Thioredoxin antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Thioredoxin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur TXN

Antigène: TXN (Thioredoxin (TXN))

Autre désignation: Thioredoxin

Sujet: Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cysteine residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds. Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations. Specific protein disulfide targets for reduction by Trx include protein disulfide isomerase(PDI) and a number of transcription factors such as p53, NF-kB and AP-1.Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins.

UniProt: P10599

Pathways: Carbohydrate Homeostasis, Cell RedoxHomeostasis