TICAM1 anticorps (AA 115-143)

N° du produit ABIN3029184

Cet anticorps anti-TICAM1 Polyclonal Lapin (ABIN3029184) détecte spécifiquement TICAM1 dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour TICAM1 anticorps (AA 115-143) (ABIN3029184)

Antigène: TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TICAM1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-TICAM1 anticorps

Épitope: AA 115-143

Fonction: TICAM1 Antibody

Purification: Antigen affinity

Immunogène: A portion of amino acids 115-143 from the human protein was used as the immunogen for this TICAM1 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the TICAM1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the TICAM1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur TICAM1

Antigène: TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))

Autre désignation: TICAM1

Sujet: Involved in innate immunity against invading pathogens. Adapter used by< a href=../search_result.php?search_txt=TLR>TLR3and< a href=../search_result.php?search_txt=TLR>TLR4(through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins< a href=../search_result.php?search_txt=Tbk1>TBK1, TRAF6 and< a href=../search_result.php?search_txt=ripk>RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7,< a href=../search_result.php?search_txt=nf-kb>NF-kappa-Band FADD respectively.

UniProt: Q8IUC6

Pathways: Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades