YAP1 anticorps (AA 420-446)

N° du produit ABIN3029661

Cet anticorps anti-YAP1 est un anticorps Lapin Polyclonal détectant YAP1 dans WB, ELISA et FACS. Adapté pour Humain.

Aperçu rapide pour YAP1 anticorps (AA 420-446) (ABIN3029661)

Antigène: YAP1 (Yes-Associated Protein 1 (YAP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp YAP1 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Détail du produit anti-YAP1 anticorps

Épitope: AA 420-446

Purification: Purified

Immunogène: A portion of amino acids 420-446 from human YAP1 was used as the immunogen for this YAP antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the YAP antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Flow Cytometry: 1:10-1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the YAP antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur YAP1

Antigène: YAP1 (Yes-Associated Protein 1 (YAP1))

Autre désignation: YAP

Sujet: YAP is a transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. [UniProt]

UniProt: P46937

Pathways: Signalisation MAPK, Stem Cell Maintenance, Regulation of Lipid Metabolism by PPARalpha