GOPC anticorps (C-Term)

N° du produit ABIN497983

Cet anticorps Lapin Polyclonal détecte spécifiquement GOPC dans WB, IHC (p) et EIA. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour GOPC anticorps (C-Term) (ABIN497983)

Antigène: GOPC (Golgi-Associated PDZ and Coiled-Coil Motif Containing (GOPC))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GOPC est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-GOPC anticorps

Épitope: C-Term

Specificité: Recognizes PIST (C-term).

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse and Rat

Purification: Immunoaffinity Chromatography

Immunogène: PIST antibody was raised against a 16 amino acid peptide from near the carboxy terminus of Human PIST

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: PIST antibody can be used for the detection of PIST at 1-2 μg/mL. Positive Control: Rat Colon Cell Lysate. Immunohistochemistry on paraffin sections. Positive Control: Rat Colon Cell Lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C. Antibodies should not be exposed to prolonged high temperatures.

Détails sur GOPC

Antigène: GOPC (Golgi-Associated PDZ and Coiled-Coil Motif Containing (GOPC))

Autre désignation: GOPC / PIST

Sujet: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2) and is negatively regulated by TOR (Target of rapamycin) (3). PIST, a PDZ-containing protein, was discovered in a yeast two-hybrid system as a binding partner to Beclin-1, a Bcl-2-interacting protein homologous to the yeast autophagy gene apg6 (4-6). Experiments with mutant PIST proteins lacking the PDZ domain showed that PIST interaction with Beclin-1 through its coiled-coil domain can modulate Beclin-1 activity and suggest that PIST interactions with other proteins through its PDZ domain may regulate the activity of PIST and Beclin-1 (6).Synonyms: CAL, CFTR-associated ligand, FIG, Fused in glioblastoma, Golgi-associated PDZ and coiled-coil motif-containing protein, PDZ protein interacting specifically with TC10

ID gène: 57120

NCBI Accession: NP_001017408

UniProt: Q9HD26

Pathways: Maintenance of Protein Location, Asymmetric Protein Localization