ATG16L1 anticorps (N-Term)

N° du produit ABIN497988

Cet anticorps anti-ATG16L1 Polyclonal Lapin (ABIN497988) détecte spécifiquement ATG16L1 dans WB, IF et EIA. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour ATG16L1 anticorps (N-Term) (ABIN497988)

Antigène: ATG16L1 (ATG16 Autophagy Related 16-Like 1 (ATG16L1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATG16L1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-ATG16L1 anticorps

Épitope: N-Term

Specificité: Recognizes ATG16 (N-term).

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse and Rat.

Purification: Immunoaffinity Chromatography

Immunogène: ATG16 antibody was raised against a 18 amino acid peptide from near the amino terminus of Human ATG16 (Genbank accession No. NP_110430).

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: ATG16 antibody can be used for the detection of ATG16 at 0.5-1 μg/mL. Immunocytochemistry. Positive Control: HeLa Cell Lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur ATG16L1

Antigène: ATG16L1 (ATG16 Autophagy Related 16-Like 1 (ATG16L1))

Autre désignation: APG16L / ATG16L1

Sujet: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG16, another member of the autophagy protein family, forms a complex with the ATG5-ATG12 conjugate. This multimeric protein has been shown to be essential for autophagosome formation in both yeast and mammals and targets the ATG5-ATG12 complex to the autophagic isolation membrane during the formation of the autophagosome. Because mammalian ATG16 has seven WD-repeats in its C-terminal domain, it has been suggested that these may form a platform for further protein-protein interactions. Multiple isoforms of ATG16 are known to exist.Synonyms: APG16-like 1, Autophagy-related protein 16-1

ID gène: 55054

NCBI Accession: NP_110430

UniProt: Q676U5

Pathways: Autophagy