PBX1 anticorps (Internal Region)

N° du produit ABIN498074

Détail du produit anti-PBX1 anticorps

Antigène: PBX1 (Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat, Chien

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp PBX1 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Séquence: C-ATNVSAHGSQ ANSPS

Réactivité croisée (Details): Species reactivity (expected):Mouse, Rat, Canine (Dog).
Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.

Immunogène: Peptide from the internal region of the protein sequence according to NP_002576.1. Genename: PBX1

Information d'application

Indications d'application: Peptide ELISA: Detection Limit: 1/32000. Western blot: 0.5-1.5 μg/mL. Detects a band of Approx 45 kDa in lysates of cell line K562.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Species Reactivity: Tested: Human. Expected from sequence similarity: Mouse, Rat, Canine (Dog). Add. Information: Calculated Molecular Weight: 46.5 kDa according to NP_002576.1

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur PBX1

Antigène: PBX1 (Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1))

Autre désignation: PBX1 (PBX1 Produits)

Synonymes: anticorps fi29e01, anticorps pbx1b, anticorps wu:fi29e01, anticorps zgc:55265, anticorps 2310056B04Rik, anticorps AI848790, anticorps AU015730, anticorps D230003C07Rik, anticorps Pbx-1, anticorps Pbx1a, anticorps Pbx1b, anticorps PBX1A, anticorps Xpbx1, anticorps Xpbx1b, anticorps PBX homeobox 1, anticorps pre-B-cell leukemia homeobox 1a, anticorps pre B cell leukemia homeobox 1, anticorps pre-B-cell leukemia homeobox 1 S homeolog, anticorps PBX1, anticorps pbx1a, anticorps Pbx1, anticorps pbx1.S

Sujet: This nonactivating protein which could be a repressor, binds the sequence 5'-ATCAATCAA-3'. It is converted into a potent transcriptional activator by the (1,19) translocation. PBX1 May have a role in steroidogenesis and subsequently sexual development and differentiation, and is expressed in all tissues except in cells of the B and T lineage. PBX1 is involved in a form of pre-B-cell acute lymphoblastic leukemia (B-ALL) (25 % of human pediatric cases) through a chromosomal translocation t(1,19)(q23,p13.3) which involves PBX1 and E2A genes. E2A-PBX1 transforms cells by constitutively activating transcription of genes regulated by PBX1 or by other members of the PBX protein family. PBX1 belongs to the TALE/PBX homeobox family, and contains 1 homeobox domain.Synonyms: Homeobox protein PBX1, Homeobox protein PRL, Pre-B-cell leukemia transcription factor 1

ID gène: 5087

NCBI Accession: NP_002576

UniProt: P40424