NEK9 anticorps

N° du produit ABIN498262

Détail du produit anti-NEK9 anticorps

Antigène: NEK9 (NIMA (Never in Mitosis Gene A)- Related Kinase 9 (NEK9))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NEK9 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificité: This antibody detects endogenous levels of Nek9 protein.

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen.

Information d'application

Indications d'application: Western blot: 1: 500 - 1: 1000. Immunoflourescence: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur NEK9

Antigène: NEK9 (NIMA (Never in Mitosis Gene A)- Related Kinase 9 (NEK9))

Autre désignation: NEK9 (NEK9 Produits)

Synonymes: anticorps NERCC, anticorps NERCC1, anticorps Nek8, anticorps NEK9, anticorps nercc, anticorps nercc1, anticorps C130021H08Rik, anticorps NIMA related kinase 9, anticorps NIMA-related kinase 9, anticorps NIMA related kinase 8, anticorps NIMA (never in mitosis gene a)-related expressed kinase 9, anticorps NIMA-related kinase 9 L homeolog, anticorps NEK9, anticorps nek9, anticorps NEK8, anticorps Nek9, anticorps nek9.L

Sujet: Nek8 (also designated never in mitosis A (NimA)-related kinase 8, Jck and NEK12A) is a mitotic regulator that plays a significant role in maintaining renal tubular integrity. Nek8 transcript is abundant in thyroid, adrenal gland and skin, with overexpression in breast tumors and infiltrating ductal carcinomas, and moderate levels in mucinous adenocarcinoma. Nek8 mutations correlate to juvenile autosomal recessive polycystic kidney disease in humans. Nek9 (never in mitosis A (NimA)-related kinase 9, Nercc1 kinase) regulates G1/S transition and S phase progression by influencing spindle dynamics and chromosome separation. Nek9 phosphorylates different histones (Histone H3 on serine and threonine), myelin basic protein, β-casein (serine) and BICD2. Nek9 interacts with Ran GTPase, Nek6, Nek7, BICD2, SSRP1 and SUPT16H/ FACT complex. Nek9 transcript is abundant in heart, liver, kidney and testis. Nek family cell-cycle protein kinases in humans have at least 11 members that share an amino-terminal catalytic domain related to NIMA, an Aspergillus nidulans kinase that plays on several aspects of mitosis, with divergent carboxyl-terminal tails of varying length.Synonyms: KIAA1995, NEK8, NERCC, NIMA-related kinase 8, Nercc1 kinase, Never in mitosis A-related kinase 9

Poids moléculaire: approx. 107.0 kDa

ID gène: 91754

NCBI Accession: NP_149107

UniProt: Q8TD19

Pathways: SARS-CoV-2 Protein Interactome, Phosphorylation & l'infection par le SRAS-CoV-2