ADRBK2 anticorps

N° du produit ABIN498279

Cet anticorps anti-ADRBK2 Polyclonal Lapin (ABIN498279) détecte spécifiquement ADRBK2 dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour ADRBK2 anticorps (ABIN498279)

Antigène: ADRBK2 (Adrenergic, Beta, Receptor Kinase 2 (ADRBK2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ADRBK2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ADRBK2 anticorps

Specificité: This antibody detects endogenous levels of GRK 3 protein. (region surrounding Phe391)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Pureté: > 95 % by SDS-PAGE

Information d'application

Indications d'application: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur ADRBK2

Antigène: ADRBK2 (Adrenergic, Beta, Receptor Kinase 2 (ADRBK2))

Autre désignation: beta-ARK-2 / ADRBK2

Sujet: Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonistmediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first are the second essenger-regulated kinases such as c-AMP dependent protein kinase A and protein kinase C. The second are the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase, GRK 1, two forms of beta-adrenergic receptor kinase, GRK 2 (betaARK, betaARK1) and GRK 3 (betaARK2), IT-11 (GRK 4), GRK 5, GRK 6 and GRK 7.Synonyms: BARK2, Beta-adrenergic receptor kinase 2, G-protein-coupled receptor kinase 3, GRK3

Poids moléculaire: approx. 80 kDa

ID gène: 157

NCBI Accession: NP_005151

UniProt: P35626

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Thromboxane A2 Receptor Signaling