CCAR2 anticorps

N° du produit ABIN498347

Détail du produit anti-CCAR2 anticorps

Antigène: CCAR2 (Cell Cycle and Apoptosis Regulator 2 (CCAR2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CCAR2 est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody detects endogenous levels of KIAA1967 / DBC-1 protein. (region surrounding Gln455)

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography

Pureté: > 95 % pure SDS-PAGE

Information d'application

Indications d'application: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 15 mM Sodium azide, approx. pH 7.2.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur CCAR2

Antigène: CCAR2 (Cell Cycle and Apoptosis Regulator 2 (CCAR2))

Autre désignation: KIAA1967 (CCAR2 Produits)

Synonymes: anticorps DBC-1, anticorps DBC1, anticorps KIAA1967, anticorps NET35, anticorps p30 DBC, anticorps p30DBC, anticorps 2610301G19Rik, anticorps mKIAA1967, anticorps RGD1309922, anticorps Kiaa1967, anticorps cell cycle and apoptosis regulator 2, anticorps cell cycle activator and apoptosis regulator 2, anticorps CCAR2, anticorps Ccar2

Sujet: KIAA1967 / DBC-1 (deleted in breast cancer gene 1 protein), also known as p30 DBC protein, is one of the genes located within the region of chromosome 8 (8p21-8p23) that is homozygously deleted in some breast cancers. DBC-1 contains a nuclear localization signal, an N-terminal leucine zipper, an EF hand and a C-terminal coiled-coil region. DBC-1 is closely related to DIS but lacks the SAP domain. During death signaling mediated by TNFα, endogenous DBC-1 undergoes caspase-dependent processing to generate DBC-1 p120 and p66, both of which include the C-terminus of the protein. Both DBC-1 p120 and p66 relocate to the cytoplasm. Overexpression of the DBC-1 p120 form results in mitochondrial clustering and matrix condensation and increases the sensitivity of cells to TNFalpha-mediated apoptosis. In addition, DBC-1 directly interacts with unliganded ERalpha, stabilizing its expression and therefore collaborating to suppress apoptosis and promote hormone-independent cell growth.Synonyms: DBC-1, DBC.1, DBC1, Deleted in breast cancer gene 1 protein, KIAA1967, p30 DBC

Poids moléculaire: approx. 102.0 kDa

ID gène: 57805

NCBI Accession: NP_066997

UniProt: Q8N163