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ADCY1 anticorps

ADCY1 Reactivité: Humain, Souris WB, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN498371
  • Antigène Voir toutes ADCY1 Anticorps
    ADCY1 (Adenylate Cyclase 1 (Brain) (ADCY1))
    Reactivité
    • 48
    • 32
    • 28
    • 4
    • 4
    • 1
    Humain, Souris
    Hôte
    • 56
    • 2
    Lapin
    Clonalité
    • 56
    • 2
    Polyclonal
    Conjugué
    • 23
    • 11
    • 8
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ADCY1 est non-conjugé
    Application
    • 39
    • 33
    • 19
    • 7
    • 7
    • 6
    • 6
    • 5
    • 2
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificité
    This antibody detects endogenous levels of A Cyclase I protein. (region surrounding Asp252)
    Réactivité croisée (Details)
    Species reactivity (expected):Mouse.
    Species reactivity (tested):Human.
    Purification
    Affinity chromatography
    Pureté
    > 95 % by SDS-PAGE
    Top Product
    Discover our top product ADCY1 Anticorps primaire
  • Indications d'application
    Western Blot: 1/500- 1/1000. Immuohistochemistry: 1/50- 1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1,0 mg/mL
    Buffer
    Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Antigène
    ADCY1 (Adenylate Cyclase 1 (Brain) (ADCY1))
    Autre désignation
    Adenylate Cyclase Type 1 (ADCY1 Produits)
    Synonymes
    anticorps AC1, anticorps D11Bwg1392e, anticorps I-AC, anticorps brl, anticorps mKIAA4070, anticorps Ac1, anticorps adenylate cyclase 1, anticorps adenylate cyclase type 1, anticorps adenylate cyclase 1 (brain), anticorps ADCY1, anticorps LOC100449504, anticorps adcy1, anticorps Adcy1
    Sujet
    Adenylyl cyclases function to convert ATP to cyclic AMP in response to activation by a variety of hormones, neurotransmitters and other regulatory molecules. Cyclic AMP, in turn, activates several other target molecules to control a broad range of diverse phenomena such as metabolism, gene transcription and memory. Adenylyl cyclases respond to receptor-initiated signals, mediated by the Gs and Gi heterotrimeric G proteins. The binding of an agonist to a Gs-coupled receptor catalyzes the exchange of GDP (bound to Galpha s) for GTP, the dissociation of GTP-Galpha s from Gbeta-gamma and Galpha s)-mediated activation of adenylyl cyclase. Adenylyl cyclases type I (AC I) and III (AC III) have distinct staining within the cell nucleus of rat brain sensory neurons. AC I is expressed in myenteric ganglia as two bands of 160 kDa and 185 kDa by SDS-PAGE. Ca2+ stimulation of AC I and AC III is mediated by calmodulin. Protein associated with Myc (PAM) is a very potent inhibitor of AC I. A decrease in endogenous PAM levels in HeLa cells modulate both basal and agonist stimulated cAMP accumulation.Synonyms: ADCY1, ATP pyrophosphate-lyase 1, Adenylate cyclase type I, Adenylyl cyclase 1, Ca(2+)/calmodulin-activated adenylyl cyclase
    Poids moléculaire
    approx. 130 kDa
    ID gène
    107
    NCBI Accession
    NP_066939
    UniProt
    Q08828
    Pathways
    EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, cAMP Metabolic Process, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma
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