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GZMH anticorps

GZMH Reactivité: Humain WB, IF, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN498458
  • Antigène Voir toutes GZMH Anticorps
    GZMH (Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) (GZMH))
    Reactivité
    • 31
    • 10
    • 2
    • 1
    Humain
    Hôte
    • 27
    • 4
    Lapin
    Clonalité
    • 29
    • 2
    Polyclonal
    Conjugué
    • 17
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp GZMH est non-conjugé
    Application
    • 16
    • 9
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificité
    This antibody detects endogenous levels of Granzyme H protein. (region surrounding Gly75)
    Réactivité croisée (Details)
    Species reactivity (tested):Human.
    Purification
    Affinity chromatography
    Pureté
    > 95 % by SDS-PAGE
    Top Product
    Discover our top product GZMH Anticorps primaire
  • Indications d'application
    Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Immunofluorescence: 1/50 - 1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1,0 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Antigène
    GZMH (Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) (GZMH))
    Autre désignation
    Granzyme H (GZMH) (GZMH Produits)
    Synonymes
    anticorps GZMH, anticorps CCP-X, anticorps CGL-2, anticorps CSP-C, anticorps CTLA1, anticorps CTSGL2, anticorps granzyme H, anticorps LOC617313, anticorps GZMH
    Sujet
    The granzyme family of proteins belong to the larger peptidase S1 family. Granzyme A and granzyme B are serine proteases that facilitate apoptotic signaling in cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Within the granules of activated CTLs, granzyme A and granzyme B are processed and converted to their active forms by the lysosomal cysteine protease cathepsin C. Once cleaved, these active proteases target distinct substrates for proteolysis and, thereby, mediate apoptosis through two different pathways. Granzyme H, also designated cytotoxic T-lymphocyte proteinase, cathepsin G-like 2 (CTSGL2) or cytotoxic serine protease C (CSP-C), contains one peptidase S1 domain. Granzyme H localizes to cytoplasmic granules of cytolytic T-lymphocytes and is important for target cell lysis in cell-mediated immune responsesSynonyms: CCP-X, CGL2, CSP-C, CTSGL2, Cathepsin G-like 2, Cytotoxic T-lymphocyte proteinase, Cytotoxic serine protease C
    Poids moléculaire
    approx. 23 kDa
    ID gène
    2999
    NCBI Accession
    NP_219491
    UniProt
    P20718
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