CBP anticorps
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- Antigène Voir toutes CBP (CREBBP) Anticorps
- CBP (CREBBP) (CREB Binding Protein (CREBBP))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp CBP est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificité
- This antibody detects endogenous levels of CBP protein. (region surrounding Glu1528)
- Réactivité croisée (Details)
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. - Purification
- Affinity Chromatography epitope-specific immunogen.
- Top Product
- Discover our top product CREBBP Anticorps primaire
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- Indications d'application
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Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Immuofluorescence: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- CBP (CREBBP) (CREB Binding Protein (CREBBP))
- Autre désignation
- CREB-Binding Protein (CREBBP Produits)
- Synonymes
- anticorps CBP, anticorps KAT3A, anticorps RSTS, anticorps AW558298, anticorps CBP/p300, anticorps p300/CBP, anticorps RTS, anticorps cbp, anticorps crebbp, anticorps kat3a, anticorps rsts, anticorps hmm291030, anticorps Nejire, anticorps CREB binding protein, anticorps CREB binding protein L homeolog, anticorps histone acetyltransferase p300, anticorps CREBBP, anticorps Crebbp, anticorps crebbp.L, anticorps LOC100123220
- Sujet
- Cyclic AMP-regulated gene expression frequently involves a DNA element designated the cAMP-regulated enhancer (CRE). Many transcription factors bind to this element, including the protein CREB, which is activated as a result of phosphorylation by protein kinase A. It has been shown that protein kinase A-mediated CREB phosphorylation results in its binding to a nuclear protein designated CBP (for CREB-binding protein). These findings suggest that CBP has many of the properties expected of a CREB co-activator. Another high molecular weight transcriptional adapter protein, designated p300, is characterized by three cysteine- and histidine-rich regions, of which the most carboxy terminal region specifically binds the adenovirus E1A protein. p300 Molecules lacking an intact E1A binding site bypass E1A repression, even in the presence of high concentrations of E1A. Sequence analysis of CBP and p300 has revealed substantial homology, arguing that these proteins are members of a conserved family of co-activators.Synonyms: CBP, CREBBP
- Poids moléculaire
- approx. 265 kDa
- ID gène
- 1387
- NCBI Accession
- NP_004371
- UniProt
- Q92793
- Pathways
- TCR Signaling, Interferon-gamma Pathway, Stem Cell Maintenance, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha
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