ROCK1 anticorps

N° du produit ABIN498550

Détail du produit anti-ROCK1 anticorps

Antigène: ROCK1 (rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ROCK1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of Rock-1 protein. (region surrounding asn311)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography using epitope-specific immunogen

Pureté: > 95 % (by SDS-PAGE)

Information d'application

Indications d'application: Immunohistochemistry on paraffin sections: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur ROCK1

Antigène: ROCK1 (rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1))

Autre désignation: ROCK1 (ROCK1 Produits)

Synonymes: anticorps LOC100229794, anticorps CG9774, anticorps DROK, anticorps DRhk, anticorps DRok, anticorps Dmel\\CG9774, anticorps Drok, anticorps ROCK, anticorps ROCK-1, anticorps ROCK1, anticorps ROK, anticorps ROKalpha/beta, anticorps Rhk, anticorps RhoK, anticorps Rock, anticorps Rok, anticorps dROK, anticorps dRok, anticorps drok, anticorps 1110055K06Rik, anticorps Rock-I, anticorps P160Rock, anticorps ROCK-I, anticorps P160ROCK, anticorps p160ROCK, anticorps Rho associated coiled-coil containing protein kinase 1, anticorps Rho kinase, anticorps Rho-associated coiled-coil containing protein kinase 1, anticorps Rho-associated, coiled-coil containing protein kinase 1, anticorps ROCK1, anticorps Rok, anticorps Rock1, anticorps rock1

Sujet: Rho, the Ras-related small GTPase, is responsible for the regulation of Actinbased cytoskeletal structures including stress fibers, focal adhesions and the contractile RING apparatus. Rho proteins function as molecular switches that are able to turn cytokinesis on and off. Although little is known about signaling downstream of Rho, a host of putative Rho effector proteins have been described, including rhophilin, Rhotekin, citron and the serine/threonine kinase, protein kinase N. Two additional Rho-activated serine/threonine kinases have been described, designated Rock-1 and Rock-2 (also referred to as Roka) for Rho-associated coil-containing protein kinase. Rock-1 and Rock-2 share a structural similarity with myotonic dystrophy kinase.Synonyms: NY-REN-35, ROCK-1, Renal carcinoma antigen NY-REN-35, Rho-associated, Rho-associated protein kinase 1, coiled-coil-containing protein kinase 1, p160ROCK

Poids moléculaire: approx. 158 kDa

ID gène: 6093

NCBI Accession: NP_005397

UniProt: Q13464

Pathways: Dynamique des Microtubules, Signalisation WNT, M Phase, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2, Thromboxane A2 Receptor Signaling