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ATP7A anticorps
ATP7A
Reactivité: Humain, Rat, Souris
IHC (p)
Hôte: Lapin
Polyclonal
unconjugated
Détail du produit anti-ATP7A anticorps
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Antigène
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ATP7A
(ATPase, Cu++ Transporting, alpha Polypeptide (ATP7A))
Reactivité
Toutes les réactivités sur ATP7A Anticorps
Humain, Rat, Souris
Hôte
Toutes les hôtes sur ATP7A Anticorps
Lapin
Clonalité
Toutes les clonalités sur ATP7A Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers ATP7A Anticorps
Cet anticorp ATP7A est non-conjugé
Application
Tous les applications à travers ATP7A Anticorps.
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Specificité
This antibody detects endogenous levels of ATP7A protein. (region surrounding His640)
Réactivité croisée (Details)
Species reactivity (expected):Mouse and Rat. Species reactivity (tested):Human.
Purification
Affinity chromatography
Pureté
> 95 % by SDS-PAGE
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Alternatives
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Information d'application
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Indications d'application
Immunohistochemistry: 1/50 - 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Stockage
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Concentration
1,0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
4 °C/-20 °C
Stockage commentaire
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Détails sur ATP7A
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Antigène
ATP7A
(ATPase, Cu++ Transporting, alpha Polypeptide (ATP7A))
Autre désignation
ATP7A (ATP7A Produits )
Synonymes
anticorps ATP7A, anticorps cal, anticorps wu:fc43e01, anticorps zgc:153422, anticorps zgc:158633, anticorps DDBDRAFT_0218568, anticorps DDBDRAFT_0235190, anticorps DDB_0218568, anticorps DDB_0235190, anticorps atpase, anticorps Atp7a, anticorps kal, anticorps atp7a, anticorps DSMAX, anticorps MK, anticorps MNK, anticorps SMAX3, anticorps Blo, anticorps DXHXS1608e, anticorps I14, anticorps Mo, anticorps blotchy, anticorps br, anticorps brindled, anticorps mottled, anticorps Mnk, anticorps ATPase copper transporting alpha, anticorps ATPase, Cu++ transporting, alpha polypeptide, anticorps P-type ATPase, anticorps ATP synthase subunit a, anticorps copper-transporting ATPase 1, anticorps ATP7A, anticorps atp7a, anticorps LOC100049514, anticorps Atp7a, anticorps LOC412379
Sujet
The copper efflux transporters ATP7A and ATP7B sequester intracellular copper into the vesicular secretory pathway for export from the cell. ATP7A functions as a transmembrane copper-translocating P-type ATPase and plays a vital role in systemic copper absorption in the gut and copper reabsorption in the kidney. Polarized epithelial cells such as Madin-Darby canine kidney cells are a physiologically relevant model for systemic copper absorption and reabsorption in vivo. Although ATP7A is not detectable in most normal tissues it is expressed in a considerable fraction of many common tumor types. Increased expression of ATP7A renders cells resistant to cisplatin and carboplatin.Synonyms: Copper pump 1, Copper-transporting ATPase 1, MC1, MNK, Menkes disease-associated protein
ID gène
538
NCBI Accession
NP_000043
UniProt
Q04656
Pathways
Transition Metal Ion Homeostasis , Ribonucleoside Biosynthetic Process
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