ATP7A anticorps (AA 42-61) (APC)

N° du produit ABIN2485190

Détail du produit anti-ATP7A anticorps (APC)

Antigène: ATP7A (ATPase, Cu++ Transporting, alpha Polypeptide (ATP7A))

Épitope: AA 42-61

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ATP7A est conjugé à/à la APC

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: Detects ~180 kDa in rat brain membrane preparations.

Réactivité croisée: Humain, Souris, Rat

Purification: Protein G Purified

Immunogène: Synthetic peptide amino acids 42-61 (cytoplasmic C-terminus) of human Copper- transporting ATPase1

Clone: S60-4

Isotype: IgG2b

Information d'application

Indications d'application:

• WB (1:500)
• ICC/IF (1:100)
• optimal dilutions for assays should be determined by the user.

Commentaires:

1 μg/ml of ABIN2485190 was sufficient for detection of Copper-transporting ATPase1 in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Conjugated antibodies should be stored at 4°C

Détails sur ATP7A

Antigène: ATP7A (ATPase, Cu++ Transporting, alpha Polypeptide (ATP7A))

Autre désignation: ATP7A (ATP7A Produits)

Synonymes: anticorps ATP7A, anticorps cal, anticorps wu:fc43e01, anticorps zgc:153422, anticorps zgc:158633, anticorps DDBDRAFT_0218568, anticorps DDBDRAFT_0235190, anticorps DDB_0218568, anticorps DDB_0235190, anticorps atpase, anticorps Atp7a, anticorps kal, anticorps atp7a, anticorps DSMAX, anticorps MK, anticorps MNK, anticorps SMAX3, anticorps Blo, anticorps DXHXS1608e, anticorps I14, anticorps Mo, anticorps blotchy, anticorps br, anticorps brindled, anticorps mottled, anticorps Mnk, anticorps ATPase copper transporting alpha, anticorps ATPase, Cu++ transporting, alpha polypeptide, anticorps P-type ATPase, anticorps ATP synthase subunit a, anticorps copper-transporting ATPase 1, anticorps ATP7A, anticorps atp7a, anticorps LOC100049514, anticorps Atp7a, anticorps LOC412379

Sujet: The copper efflux transporters ATP7A and ATP7B sequester intracellular copper into the vesicular secretory pathway for export from the cell. ATP7A (also known as Copper-transporting ATPase 1) functions as a transmembrane copper-trans locating P-type ATPase and plays a vital role in systemic copper absorption in the gut and copper reabsorption in the kidney. Polarized epithelial cells such as Madin-Darby canine kidney cells are a physiologically relevant model for systemic copper absorption and reabsorption in vivo. Although ATP7A is not detectable in most normal tissues, it is expressed in a considerable fraction of many common tumor types. Increased expression of ATP7A renders cells resistant to cisplatin and carboplatin. Mutations in the ATP7A gene result in Menkes disease, which is fatal in early childhood. Mutations in the ATP7B gene lead to the autosomal recessive disorder, Wilson disease, characterized by neurological symptoms and hepatic damage.

ID gène: 538

NCBI Accession: NP_000043

UniProt: Q04656

Pathways: Transition Metal Ion Homeostasis, Ribonucleoside Biosynthetic Process