TAL1 anticorps

N° du produit ABIN499039

Détail du produit anti-TAL1 anticorps

Antigène: TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TAL1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of TAL1 protein. (region surrounding Gly116)

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse.

Purification: Affinity Chromatography using epitope-specific immunogen.

Information d'application

Indications d'application: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur TAL1

Antigène: TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))

Autre désignation: TAL1 (TAL1 Produits)

Synonymes: anticorps SCL/tal-1, anticorps Scl, anticorps bHLHa17, anticorps tal-1, anticorps SCL, anticorps TCL5, anticorps scl, anticorps tcl5, anticorps SCL-alpha, anticorps SCL-beta, anticorps scl/tal1, anticorps zgc:85605, anticorps T cell acute lymphocytic leukemia 1, anticorps TAL bHLH transcription factor 1, erythroid differentiation factor, anticorps T-cell acute lymphocytic leukemia 1 S homeolog, anticorps T-cell acute lymphocytic leukemia 1, anticorps Tal1, anticorps TAL1, anticorps tal1.S, anticorps tal1

Sujet: Activation of TAL1 characterizes up to 60 % of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase IIalpha, a serine/ threonine protein kinase known to modulate the activity of other bHLH transcription factors.Synonyms: SCL, Stem cell protein, T-cell acute lymphocytic leukemia protein 1, T-cell leukemia/lymphoma protein 5, TAL-1, TCL5

Poids moléculaire: approx. 45 kDa

ID gène: 6886

NCBI Accession: NP_003180

UniProt: P17542

Pathways: Stem Cell Maintenance