SIGLEC6 anticorps (Internal Region)

N° du produit ABIN499145

Détail du produit anti-SIGLEC6 anticorps

Antigène: SIGLEC6 (Sialic Acid Binding Ig-Like Lectin 6 (SIGLEC6))

Épitope: Internal Region

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp SIGLEC6 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Séquence: C-KWMKYGYTSS K

Specificité: This antibody is expected to recognize all reported isoforms (NP_001236.4, NP_942142.3, NP_942143.3).

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.

Immunogène: Peptide with sequence from the internal region of the protein sequence according to NP_001236.4, NP_942142.3 and NP_942143.3. Genename: SIGLEC6

Information d'application

Indications d'application: Peptide ELISA: Limit Dilution: 1/16000. Western blot: 0.5-1.5 μg/mL. This antibody detects bands at approx. 60 kDa and 30 kDa in HumanPlacenta lysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur SIGLEC6

Antigène: SIGLEC6 (Sialic Acid Binding Ig-Like Lectin 6 (SIGLEC6))

Autre désignation: CD327 / SIGLEC6 (SIGLEC6 Produits)

Synonymes: anticorps SIGLEC6, anticorps CD327, anticorps CD33L, anticorps CD33L1, anticorps CD33L2, anticorps CDW327, anticorps OBBP1, anticorps sialic acid binding Ig like lectin 6, anticorps SIGLEC6

Sujet: SIGLEC6 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells by binding to alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC6, which interacts with LEP, is expressed at high levels in placenta (cyto-and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine. It contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The gene for SIGLEC6 belongs to the immunoglobulin superfamily.Synonyms: CD33 antigen-like 1, CD33L, CD33L1, CDw327, OB-BP1, OBBP1, Obesity-binding protein 1, Sialic acid-binding Ig-like lectin 6, Siglec-6

ID gène: 946

NCBI Accession: NP_001236

UniProt: O43699