ACIN1 anticorps (Intermediate Domain)

N° du produit ABIN499201

Cet anticorps Lapin Polyclonal détecte spécifiquement ACIN1 dans WB, IF et EIA. Il présente une réactivité envers Humain.

Aperçu rapide pour ACIN1 anticorps (Intermediate Domain) (ABIN499201)

Antigène: ACIN1 (Apoptotic Chromatin Condensation Inducer 1 (ACIN1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ACIN1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-ACIN1 anticorps

Épitope: Intermediate Domain

Specificité: Acinus antibody was raised against a peptide corresponding to amino acids 775 to 789 of Human AcinusL, 48 to 62 of human AcinusS', or 17 to 31 of human AcinusS, which differ from those of mouse Acinus by one amino acid .

Purification: Affinity chromatography purified via peptide column

Immunogène: Human Acinus (Intermediate Domain) Peptide

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: Acinus antibody can be used for detection of Acinus at 0.5 to 1 μg/mL. A 220 kDa band can be detected. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur ACIN1

Antigène: ACIN1 (Apoptotic Chromatin Condensation Inducer 1 (ACIN1))

Autre désignation: Acinus / ACIN1

Sujet: Chromatin condensation and nuclear fragmentation (CCNF) is the hallmark of apoptosis. CCNF is triggered by the activation of members of caspase family, caspase activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE . A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by caspase-3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse and designated AcinusL, AcinusS and AcinusS (2).Synonyms: Apoptotic chromatin condensation inducer in the nucleus, KIAA0670

ID gène: 22985

UniProt: Q9UKV3