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FYB anticorps (N-Term)

FYB Reactivité: Humain WB, IF, EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN499217
  • Antigène Voir toutes FYB Anticorps
    FYB (FYN-Binding Protein (FYB))
    Épitope
    • 15
    • 12
    • 8
    • 6
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 51
    • 8
    • 7
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    Humain
    Hôte
    • 42
    • 8
    • 1
    Lapin
    Clonalité
    • 43
    • 8
    Polyclonal
    Conjugué
    • 27
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp FYB est non-conjugé
    Application
    • 35
    • 26
    • 13
    • 13
    • 7
    • 7
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Specificité
    This antibody reacts to ADAP.
    Purification
    Affinity chromatography purified via peptide column
    Immunogène
    ADAP antibody was raised against a 17 amino acid peptide from near the amino terminus of human ADAP.
    Isotype
    IgG
    Top Product
    Discover our top product FYB Anticorps primaire
  • Indications d'application
    ELISA. Western Blot: ADAP antibody can be used for detection of ADAP at 0.5 - 1 μg/mL. Immunocytochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % Sodium Azide as preservative
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C.
  • Antigène
    FYB (FYN-Binding Protein (FYB))
    Autre désignation
    FYN-Binding Protein (FYB Produits)
    Synonymes
    anticorps fyb, anticorps ADAP, anticorps PRO0823, anticorps SLAP-130, anticorps B630013F22Rik, anticorps FYB-120/130, anticorps Slap130, anticorps p120/130, anticorps p120/p130, anticorps RGD1563421, anticorps FYN-binding protein, anticorps FYN binding protein 1, anticorps FYN binding protein, anticorps fyb, anticorps FYB1, anticorps Fyb, anticorps Fyb1
    Sujet
    The adhesion and degranulation adaptor protein (ADAP) was initially identified as a molecular adapter that couples T cell receptor (TCR) stimulation to the avidity of integrins governing T cell adhesion. TCR stimulation promotes the formation of a multi-protein complex containing CARMA1, MALT1, and BCL-10, which through the association of ADAP, ultimately activates the NF-kappaB family of transcription factors. More recent experiments have shown that ADAP controls optimal T cell proliferation, cytokine production, and expression of the Bcl-2 family member Bcl-x(L), suggesting that ADAP regulates T cell activation by promoting antigen-dependent T cell-antigen presenting cell (APC) activation. At least three isoforms of ADAP are known to exist.Synonyms: Adhesion and degranulation promoting adaptor protein, FYB-120/130, FYN-T-binding protein, SLAP-130, SLAP130, SLP-76-associated phosphoprotein, p120/p130
    ID gène
    2533
    NCBI Accession
    NP_955367
    UniProt
    O15117
    Pathways
    TCR Signaling, Protein targeting to Nucleus
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