BIK anticorps (N-Term)

N° du produit ABIN499467

Cet anticorps anti-BIK est un anticorps Lapin Polyclonal détectant BIK dans WB, IF et EIA. Adapté pour Humain et Souris.

Aperçu rapide pour BIK anticorps (N-Term) (ABIN499467)

Antigène: BIK (BCL2-Interacting Killer (Apoptosis-Inducing) (BIK))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BIK est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-BIK anticorps

Épitope: N-Term

Specificité: This anitbody reacts to BIK.

Purification: Affinity chromatography purified via peptide column

Immunogène: BIK antibody was raised against a 15 amino acid peptide from near the amino terminus of human BIK.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: BIK antibody can be used for the detection of BIK ot at 1 - 2 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur BIK

Antigène: BIK (BCL2-Interacting Killer (Apoptosis-Inducing) (BIK))

Autre désignation: BIK

Sujet: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells and is caused by the activation of proteolytic enzymes termed caspases. Proteins that comprise the Bcl-2 family appear to control the activation of these enzymes. One such protein BIK was recently identified as an endoplasmic reticulum (ER)-residing pro-apoptotic member of the Bcl-2 homology domain-3 (BH3)-only group of the Bcl-2 family that stimulates mitochondrial release of cytochrome c following p53 induction of apoptosis. A significant fraction of BIK is found as an ER transmembrane protein, with most of the protein facing the cytosol. Restricting BIK to the ER membrane by replacing the transmembrane region with that of the ER-selective membrane anchor of cytochrome b(5) resulted in a decreased cytochrome c release from mitochondria and a corresponding drop in cell death. Recent evidence suggests that BIK cooperates with NOXA, another BH3-only protein, to somehow enhance the activation of Bax to stimulate the rapid release of cytochrome c from mitochondria.Synonyms: Apoptosis inducer NBK, BIP1, BP4, Bcl-2-interacting killer, NBK

ID gène: 638

UniProt: Q13323

Pathways: Positive Regulation of Endopeptidase Activity