BIK anticorps (N-Term)
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- Antigène Voir toutes BIK Anticorps
- BIK (BCL2-Interacting Killer (Apoptosis-Inducing) (BIK))
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Épitope
- N-Term
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp BIK est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
- Specificité
- This anitbody reacts to BIK.
- Purification
- Affinity chromatography purified via peptide column
- Immunogène
- BIK antibody was raised against a 15 amino acid peptide from near the amino terminus of human BIK.
- Isotype
- IgG
- Top Product
- Discover our top product BIK Anticorps primaire
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- Indications d'application
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ELISA. Western Blot: BIK antibody can be used for the detection of BIK ot at 1 - 2 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Buffer
- PBS containing 0.02 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C.
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- Antigène
- BIK (BCL2-Interacting Killer (Apoptosis-Inducing) (BIK))
- Autre désignation
- BIK (BIK Produits)
- Synonymes
- anticorps BIK, anticorps Biklk, anticorps Blk, anticorps Nbk, anticorps BIP1, anticorps BP4, anticorps NBK, anticorps si:dkey-31f5.6, anticorps BCL2 interacting killer, anticorps BCL2-interacting killer, anticorps BCL2-interacting killer (apoptosis-inducing), anticorps BIK, anticorps Bik, anticorps bik
- Sujet
- Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells and is caused by the activation of proteolytic enzymes termed caspases. Proteins that comprise the Bcl-2 family appear to control the activation of these enzymes. One such protein BIK was recently identified as an endoplasmic reticulum (ER)-residing pro-apoptotic member of the Bcl-2 homology domain-3 (BH3)-only group of the Bcl-2 family that stimulates mitochondrial release of cytochrome c following p53 induction of apoptosis. A significant fraction of BIK is found as an ER transmembrane protein, with most of the protein facing the cytosol. Restricting BIK to the ER membrane by replacing the transmembrane region with that of the ER-selective membrane anchor of cytochrome b(5) resulted in a decreased cytochrome c release from mitochondria and a corresponding drop in cell death. Recent evidence suggests that BIK cooperates with NOXA, another BH3-only protein, to somehow enhance the activation of Bax to stimulate the rapid release of cytochrome c from mitochondria.Synonyms: Apoptosis inducer NBK, BIP1, BP4, Bcl-2-interacting killer, NBK
- ID gène
- 638
- UniProt
- Q13323
- Pathways
- Positive Regulation of Endopeptidase Activity
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