BMI1 anticorps (Intermediate Domain)

N° du produit ABIN499483

Cet anticorps Lapin Polyclonal détecte spécifiquement BMI1 dans WB, IF et EIA. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour BMI1 anticorps (Intermediate Domain) (ABIN499483)

Antigène: BMI1 (BMI1 Polycomb Ring Finger Oncogene (BMI1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BMI1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-BMI1 anticorps

Épitope: Intermediate Domain

Specificité: BMI-1 antibody was raised against a peptide corresponding to 15 amino acids near the center of human BMI-1.

Purification: Affinity chromatography purified via peptide column

Immunogène: Human BMI-1 (Intermediate Domain) Peptide

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: BMI-1 antibody can be used for detection of BMI-1 at 0.5 to 1 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur BMI1

Antigène: BMI1 (BMI1 Polycomb Ring Finger Oncogene (BMI1))

Autre désignation: BMI-1 / RNF51

Sujet: The transcriptional repressor BMI-1 was first identified as a proto-oncogene frequently activated by Moloney murine leukemia proviral insertions in mice and cooperating with c-myc in the generation of mouse lymphomas . BMI-1 is involved in segment specification, cell growth and maintenance, transcriptional regulation, and chromatin modification. A major target of BMI-1 is the ink4a locus which encodes tumor suppressor proteins p16 and p19Arf, which are important in tumor progression and thought to be critical in cell proliferation and senescence (2). Recent studies have also shown that BMI-1 is required for the maintenance of adult normal and leukemic stem cells (3), suggesting that BMI-1 could an attractive therapeutic target for stem cell proliferation and renewal as well as for anti-cancer strategies.Synonyms: BMI1, PCGF4, Polycomb group RING finger protein 4, RING finger protein 51

ID gène: 648

UniProt: P35226

Pathways: Cycle Cellulaire, Autophagy