BRE anticorps (N-Term)

N° du produit ABIN499497

Cet anticorps anti-BRE est un anticorps Polyclonal produit chez le Lapin, détectant BRE dans WB, IHC (p) et EIA. Convient pour Humain, Souris et Rat.

Aperçu rapide pour BRE anticorps (N-Term) (ABIN499497)

Antigène: BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BRE est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-BRE anticorps

Épitope: N-Term

Specificité: This antibody reacts to BRCC45.

Purification: Affinity chromatography purified via peptide column

Immunogène: BRCC45 antibody was raised against a 18 amino acid peptide from near the amino terminus of human BRCC45.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: BRCC45 antibody can be used for detection of BRCC45 at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur BRE

Antigène: BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))

Autre désignation: BRE / BRCC45

Sujet: BRCC45 was initially suggested to be a housekeeping protein that is highly expressed in brain and reproductive organs. Later experiments indicated BRCC45 forms a complex with the breast and ovarian predisposition proteins BRCA1 and BRCA2 as well as RAD51 and BRCC36. This complex has a ubiquitin E3 ligase activity and is thought to enhance cellular survival following DNA damage. BRCC45 has also been suggested to function as a death receptor-associated anti-apoptotic protein by inhibiting the BID-induced activation of the mitochondrial apoptotic pathway. Higher levels of BRCC45 were detected in the majority of hepatocellular carcinomas, suggesting that BRCC45 may promote tumorigenesis when overexpressed. At least three isoforms of BRCC45 are known to exist.Synonyms: BRCA1-A complex subunit BRE, BRCA1/BRCA2-containing complex subunit 45, BRCC45, BRE, Brain and reproductive organ-expressed protein

ID gène: 9577

NCBI Accession: NP_004890

UniProt: Q9NXR7

Pathways: Positive Regulation of Response to DNA Damage Stimulus