CARD8 anticorps

N° du produit ABIN499535

L’anticorps Lapin Polyclonal anti-CARD8 a été validé pour WB, IF et EIA. Il convient pour détecter CARD8 dans des échantillons de Humain.

Aperçu rapide pour CARD8 anticorps (ABIN499535)

Antigène: CARD8 (Caspase Recruitment Domain Family, Member 8 (CARD8))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CARD8 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-CARD8 anticorps

Specificité: CARD8 antibody was raised against a synthetic peptide corresponding to amino acids at the C-terminus of human CARD8.

Purification: Affinity chromatography purified via peptide column

Immunogène: Human CARD8 / Cardinal / TUCAN Peptide

Isotype: IgG

Information d'application

Indications d'application: ELISA. Immunocytochemistry. Western Blot: CARD8 antibody can be used for detection of CARD8 at 2 μg/mL. K562 cell lysate can be used as Positive Control and a band at approximately 45 kDa canbe detected.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur CARD8

Antigène: CARD8 (Caspase Recruitment Domain Family, Member 8 (CARD8))

Autre désignation: CARD8 / NDPP1

Sujet: Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, BCL-10, and ASC. A novel CARD-containing protein was recently identified and designated CARD8. This protein interacts with DRAL, a p53-responsive protein implicated in the induction of apoptosis (1,2), and caspase-1 and its related proteins ICEBERG and pesudo-ICE (3). Although there are conflicting reports on whether CARD8 acts a pro- or anti-apoptotic protein (2,4), it has been suggested that it functions as an adaptor molecule regulating caspase-1 and NF-kappaB activation.Synonyms: Apoptotic protein NDPP-1, CARD-inhibitor of NF-kappa-B-activating ligand, CARDINAL, Caspase recruitment domain-containing protein 8, DACAR, KIAA0955, TUCAN, Tumor up-regulated CARD-containing antagonist of CASP9

ID gène: 22900

UniProt: Q9Y2G2

Pathways: Positive Regulation of Endopeptidase Activity