CARD11 anticorps

N° du produit ABIN499539

Cet anticorps anti-CARD11 est un anticorps Lapin Polyclonal détectant CARD11 dans WB, IHC (p) et EIA. Adapté pour Humain et Souris.

Aperçu rapide pour CARD11 anticorps (ABIN499539)

Antigène: CARD11 (Caspase Recruitment Domain Family, Member 11 (CARD11))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CARD11 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-CARD11 anticorps

Specificité: CARMA1 antibody was raised against a synthetic peptide corresponding to amino acids at the C-terminus of human CARMA1.

Purification: Affinity chromatography purified via peptide column

Immunogène: Human CARMA1 Peptide

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: CARMA1 antibody can be used for detection of CARMA1 at 0.5 to 2 μg/mL. Aband at approximately 125 kDa can be detected. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur CARD11

Antigène: CARD11 (Caspase Recruitment Domain Family, Member 11 (CARD11))

Autre désignation: CARD11 / CARMA1

Sujet: CARMA proteins belong to the membrane-associated guan-ylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules (1). CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types (2-4). Both CARMA1 and CARMA3 associate with NEMO, the regulatory subunit of the I?K complex, thereby regulating activation of the NF-kappaB transcription factor (5). Also, gene inactivation studies showed a complete block in T and B cell immunity as well as an impaired response to LPS, indicating that CARMA1 is a critical regulator in both the adaptive and innate immune systems (6).Synonyms: CARD-containing MAGUK protein 3, Caspase recruitment domain-containing protein 11

ID gène: 84433

UniProt: Q9BXL7

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, BCR Signaling