CNOT4 anticorps (N-Term)

N° du produit ABIN499646

L’anticorps Lapin Polyclonal anti-CNOT4 a été validé pour WB et EIA. Il convient pour détecter CNOT4 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour CNOT4 anticorps (N-Term) (ABIN499646)

Antigène: CNOT4 (CCR4-NOT Transcription Complex Subunit 4 (CNOT4))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CNOT4 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-CNOT4 anticorps

Épitope: N-Term

Specificité: This antibody reacts to CNOT4.

Purification: Affinity chromatography purified via peptide column

Immunogène: CNOT4 antibody was raised against a 19 amino acid peptide near the amino terminus of the human CNOT4.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: CNOT4 antibody can be used for detection of CNOT4 at 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur CNOT4

Antigène: CNOT4 (CCR4-NOT Transcription Complex Subunit 4 (CNOT4))

Autre désignation: CNOT4

Sujet: CNOT4 is a component of the CCR4-NOT transcription complex, a complex that is implicated in the repression of RNA polymerase II transcription. In the CCR4-NOT complex, CNOT4 acts as an E3 ubiquitin-protein ligase and interacts with a subset of E2 ubiquitin-conjugating enzymes through a unique C4C4 RING domain. This E3 ligase activity was shown to be dependent on the selective and specific interaction with the ubiquitin conjugating enzyme UbcH5B. In yeast, mutations in CNOT4 that prevented its interaction with the UbcH5B homolog UBC4 caused increased sensitivity to hydroxyurea, heat shock, and hygromycin B, suggesting that CNOT4 and UbcH5B are involved in stress response in vivo. Multiple isoforms of CNOT4 are known to exist.Synonyms: CCR4-NOT transcription complex subunit 4, CCR4-associated factor 4, E3 ubiquitin-protein ligase CNOT4, NOT4, NOT4Hp, Potential transcriptional repressor NOT4Hp

ID gène: 4850

NCBI Accession: NP_037448

UniProt: O95628