DAPK2 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human DAPK2. The sequence of this antigenic peptide is identical to the corresponding amino acids of mouse origin (1,2). DAPK2 has no cross responses to DAPK1.
Purification
Affinity chromatography purified via peptide column
ELISA. Western Blot: 0.5 to 1 μg/mL. An approximately 42 kDa band can be detected. Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Buffer
PBS containing 0.02 % sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
anticorps drp1, anticorps drp-1, anticorps DAPK2, anticorps dapk2, anticorps DRP-1, anticorps DRP1, anticorps death-associated protein kinase 2 L homeolog, anticorps death associated protein kinase 2, anticorps death-associated protein kinase 2b, anticorps death-associated protein kinase 2, anticorps dapk2.L, anticorps DAPK2, anticorps dapk2b, anticorps dapk2, anticorps Dapk2
Sujet
Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as RIP and DAP kinase, are mediators of apoptosis. DAP kinase (DAPK) is pro-apoptotic calcium-regulated serine/threonine kinase containing death domain. Ectopic expression of DAPK induces cell death and suppresses oncogenic transformation. DAPK mediates IFNg induced apoptosis. A novel DAP kinase-related protein was recently identified and designated DAPK2 and DRP-1 (1, 2). Ectopicly expressed DAPK2 induced apoptosis in various types of cells (1,2). DAPK has high sequence homology to ZIP kinase and DRAK1/2, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. The messenger RNA of DAPK2 is expressed in multiple human tissues (1).Synonyms: DAP kinase 2, DAP-kinase-related protein 1, Death-associated protein kinase 2