Beclin 1 anticorps (AA 160-190)
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- Antigène Voir toutes Beclin 1 (BECN1) Anticorps
- Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))
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Épitope
- AA 160-190
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Reactivité
- Humain, Souris, Rat
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp Beclin 1 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Réactivité croisée
- Humain, Souris, Rat
- Purification
- Purified by Protein G.
- Immunogène
- KLH conjugated synthetic peptide derived from human Beclin 1
- Clone
- 7B12
- Isotype
- IgG
- Top Product
- Discover our top product BECN1 Anticorps primaire
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- Indications d'application
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WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))
- Autre désignation
- Beclin 1 (BECN1 Produits)
- Synonymes
- anticorps beclin-1, anticorps atg6, anticorps vps30, anticorps beclin1, anticorps Beclin-1, anticorps becn1, anticorps zgc:73097, anticorps ATG6, anticorps VPS30, anticorps 4921513J16Rik, anticorps 5430417M23Rik, anticorps Atg6, anticorps beclin 1, anticorps beclin 1, autophagy related, anticorps beclin 1 protein, anticorps beclin-1, anticorps beclin family protein, anticorps beclin 1, autophagy related L homeolog, anticorps BECN1, anticorps becn1, anticorps atg6, anticorps CpipJ_CPIJ011087, anticorps PTRG_07825, anticorps SJAG_01876, anticorps Becn1, anticorps becn1.L
- Sujet
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Synonyms: Beclin-1, BECN1, Coiled-coil myosin-like BCL2-interacting protein, Protein GT197
Background: Plays a central role in autophagy (PubMed:23184933). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate, different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense. Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis, it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.
- ID gène
- 8678
- UniProt
- Q14457
- Pathways
- Autophagy
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