DFFA anticorps (N-Term)
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- Antigène Voir toutes DFFA Anticorps
- DFFA (DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA))
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Épitope
- N-Term
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp DFFA est non-conjugé
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Application
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Specificité
- DFF45 antibody was raised against a peptide corresponding to amino acids 2 to 21 of human DFF45.
- Purification
- DEAE
- Immunogène
- Human DFF45 (N-Terminus) Peptide
- Isotype
- IgG
- Top Product
- Discover our top product DFFA Anticorps primaire
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- Indications d'application
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ELISA. Western Blot: DFF45 antibody can be used for detection of DFF45, DFF35, and one thecleaved fragment at 1/1000 to 1/2000 dilution.45 and 35 kDa bands can be detected innon-apoptotic cells.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Buffer
- PBS containing 0.02 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C.
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- Antigène
- DFFA (DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA))
- Autre désignation
- DFFA / ICAD (DFFA Produits)
- Synonymes
- anticorps DFF-45, anticorps DFF1, anticorps ICAD, anticorps A330085O09Rik, anticorps DFF35, anticorps Dff45, anticorps ICAD-L, anticorps ICAD-S, anticorps DFFA, anticorps zgc:92229, anticorps DNA fragmentation factor subunit alpha, anticorps DNA fragmentation factor, alpha subunit, anticorps DNA fragmentation factor, 45kDa, alpha polypeptide, anticorps DNA fragmentation factor, alpha polypeptide, anticorps DFFA, anticorps Dffa, anticorps dffa
- Sujet
- Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A human 45 kDa DNA fragmentation factor (DFF45) was identified recently that was cleaved by caspase-3 during apoptosis. Mouse homologue of human DFF45 was identified as a DNase inhibitor designated ICAD. DFF45/ICAD have short forms that were termed DFF35 and ICADs, respectively. Upon cleavage of DFF45/ICAD, the caspase activated deoxyribonuclease (DFF40/CAD) is released and activated and eventually causes the degradation of DNA in the nuclei. Therefore, the cleavage of DFF45/ICAD, which causes DFF40/CAD activation and DNA degradation, is the hallmark of apoptotic cell death.Synonyms: DFF-45, DFF1, DFF45, DNA fragmentation factor 45 kDa subunit, DNA fragmentation factor subunit alpha, Inhibitor of CAD
- ID gène
- 1676
- NCBI Accession
- NP_004392
- UniProt
- O00273
- Pathways
- Apoptose, Caspase Cascade in Apoptosis
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