DISP2 anticorps (C-Term)

N° du produit ABIN499750

Détail du produit anti-DISP2 anticorps

Antigène: DISP2 (Dispatched Homolog 2 (DISP2))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DISP2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to Disp2.

Purification: Affinity chromatography purified via peptide column

Immunogène: Disp2 antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human Disp2.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: Disp2 antibody can be used for the detection of Disp2 by Western blot at 1 -2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur DISP2

Antigène: DISP2 (Dispatched Homolog 2 (DISP2))

Autre désignation: DISP2 / DISPB (DISP2 Produits)

Synonymes: anticorps DISP2, anticorps DISPB, anticorps HsT16908, anticorps AI840597, anticorps B230210L08Rik, anticorps DispB, anticorps mKIAA1742, anticorps dispatched RND transporter family member 2, anticorps dispatched RND tramsporter family member 2, anticorps dispatched homolog 2 (Drosophila), anticorps DISP2, anticorps Disp2

Sujet: Disp2 is the second of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the Disp proteins have been implicated in these pathways. Recently, it has been shown that Disp2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased Disp2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by Disp2 mutants. At least two isoforms of Disp2 are known to exist. This Disp2 antibody is predicted to not cross-react with Disp1 or Disp3.Synonyms: KIAA1742, Protein dispatched homolog 2

ID gène: 85455

UniProt: A7MBM2

Pathways: Signalisation Hedgehog