FAF1 anticorps (C-Term)

N° du produit ABIN499818

Cet anticorps anti-FAF1 est un anticorps Lapin Polyclonal détectant FAF1 dans WB, IHC (p) et EIA. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour FAF1 anticorps (C-Term) (ABIN499818)

Antigène: FAF1 (Fas (TNFRSF6) Associated Factor 1 (FAF1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FAF1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-FAF1 anticorps

Épitope: C-Term

Specificité: This antibody reacts to FAF1.

Purification: Affinity chromatography purified via peptide column

Immunogène: FAF1 antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human FAF1.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur FAF1

Antigène: FAF1 (Fas (TNFRSF6) Associated Factor 1 (FAF1))

Autre désignation: FAF1

Sujet: Fas-associated protein 1 (FAF1) was initially identified as a Fas-binding pro-apoptotic protein that is component of the death-inducing signaling complex in Fas-mediated apoptosis (1). FAF1 can also induce apoptosis in the absence of extrinsic death signals when overexpressed although it does not contain typical death motifs such as the death domain, death effector domain, and caspase recruitment domain (1,2). Overexpression of FAF1 also decreases the basal level of NF-kappaB activity in transfected 293 cells, inhibits NF-kappaB activity induced by TNF-alpha, IL-1beta and lipopolysaccharide, and prevents NF-kappaB translocation to the nucleus (3), suggesting that another role of FAF1 is to negatively regulate the activity of NF-kappaB. FAF1 can also interact with the inflammatory signaling PYRIN-containing Apaf-1-like proteins (PYPAFs, also called NALPs) such as PYPAF1, PYPAF2 (NALP2), and PYPAF7, suggesting FAF1 may also be involved in the inflammation pathway (4). Multiple differentially spliced isoforms of FAF1 are known to exist.Synonyms: CGI-03, FAS-associated factor 1, UBX domain-containing protein 12, UBX domain-containing protein 3A, UBXD12, UBXN3A

ID gène: 11124

NCBI Accession: NP_008982

UniProt: Q9UNN5

Pathways: Maintenance of Protein Location