FAM120A anticorps (Center)

N° du produit ABIN499822

Cet anticorps Lapin Polyclonal détecte spécifiquement FAM120A dans WB, IF, IHC (p) et EIA. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour FAM120A anticorps (Center) (ABIN499822)

Antigène: FAM120A (Family with Sequence Similarity 120A (FAM120A))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FAM120A est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-FAM120A anticorps

Épitope: Center

Specificité: This antibody reacts to FAM120A.

Purification: Affinity chromatography purified via peptide column

Immunogène: FAM120A antibody was raised against an 18 amino acid peptide from near the center of human FAM120A.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: 0.5 - 1 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur FAM120A

Antigène: FAM120A (Family with Sequence Similarity 120A (FAM120A))

Autre désignation: FAM120A

Sujet: FAM120A (C9orf10) is a member of the constitutive coactivator of PPAR gamma family and the gene was mapped to chromosome 9q22.31. FAM120A was recently detected within the Pur-alpha-containing mRNA-protein complex in the brain. As a novel RNA-binding protein, FAM120A is a critical component of the oxidative stress-induced survival signaling. It may participate in mRNA transport in the cytoplasm. FAM120A activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. FAM120A protects cells from apoptosis through activation of SRKs in response to oxidative stress. Blocking of the survival signaling mediated by FAM120A, which sensitizes the cancer cells to stress-induced apoptosis, may be a novel therapeutic approach for gastric scirrhous carcinoma cells.Synonyms: C9orf10, Constitutive coactivator of PPAR-gamma-like protein 1, KIAA0183, OSSA, Oxidative stress-associated Src activator, Protein FAM120A

ID gène: 23196

NCBI Accession: NP_055427

UniProt: Q9NZB2