FLASH anticorps (C-Term)

N° du produit ABIN499842

Cet anticorps anti-FLASH est un anticorps Lapin Polyclonal détectant FLASH dans WB, IF et EIA. Adapté pour Humain.

Aperçu rapide pour FLASH anticorps (C-Term) (ABIN499842)

Antigène: FLASH (CASP8AP2) (CASP8 Associated Protein 2 (CASP8AP2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FLASH est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-FLASH anticorps

Épitope: C-Term

Specificité: FLASH antibody was raised against a synthetic peptide corresponding to amino acids near the carboxy-terminus of human FLASH which differ from those of mouse by one amino acid.

Purification: Affinity chromatography purified via peptide column

Immunogène: Human FLASH (C-Terminus) Peptide

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: 0.25 to 0.5 μg/mL. An approximate 220 kDa band can be detected. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur FLASH

Antigène: FLASH (CASP8AP2) (CASP8 Associated Protein 2 (CASP8AP2))

Autre désignation: CASP8AP2 / FLASH

Sujet: A novel mammalian CED-4 homologous was recently identified and cloned in mouse (1) and human (2) and designated FLASH (for FLICE-associated huge protein). FLASH is involved in Fas induced apoptosis. It is recruited to Fas after the receptor cross-linking. Overexpression of wild type of FLASH facilitates and its dominant negative form inhibits Fas induced apoptosis. FLASH interacts with the DEDs of caspase-8 and FADD through the DED-like domain of FLASH and mediates activation of caspase-8 (1). There are parallels between FLASH and Apaf-1/CED-4 although there are arguments against their structural similarity (1,2). FLASH is widely expressed.Synonyms: CASP8-associated protein 2, KIAA1315, RIP25

ID gène: 9994

UniProt: Q9Y563

Pathways: Chromatin Binding, Positive Regulation of Endopeptidase Activity