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FLASH anticorps (C-Term)

CASP8AP2 Reactivité: Humain WB, IF, EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN499842
  • Antigène Voir toutes FLASH (CASP8AP2) Anticorps
    FLASH (CASP8AP2) (CASP8 Associated Protein 2 (CASP8AP2))
    Épitope
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 16
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 18
    Lapin
    Clonalité
    • 18
    Polyclonal
    Conjugué
    • 11
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp FLASH est non-conjugé
    Application
    • 11
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Specificité
    FLASH antibody was raised against a synthetic peptide corresponding to amino acids near the carboxy-terminus of human FLASH which differ from those of mouse by one amino acid.
    Purification
    Affinity chromatography purified via peptide column
    Immunogène
    Human FLASH (C-Terminus) Peptide
    Isotype
    IgG
    Top Product
    Discover our top product CASP8AP2 Anticorps primaire
  • Indications d'application
    ELISA. Western Blot: 0.25 to 0.5 μg/mL. An approximate 220 kDa band can be detected. Immunocytochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C.
  • Antigène
    FLASH (CASP8AP2) (CASP8 Associated Protein 2 (CASP8AP2))
    Autre désignation
    CASP8AP2 / FLASH (CASP8AP2 Produits)
    Synonymes
    anticorps CASP8AP2, anticorps FLASH, anticorps fc74h10, anticorps wu:fc74h10, anticorps zgc:113449, anticorps CED-4, anticorps RIP25, anticorps AA387232, anticorps D4Ertd659e, anticorps mKIAA1315, anticorps caspase 8 associated protein 2, anticorps CASP8AP2, anticorps casp8ap2, anticorps Casp8ap2
    Sujet
    A novel mammalian CED-4 homologous was recently identified and cloned in mouse (1) and human (2) and designated FLASH (for FLICE-associated huge protein). FLASH is involved in Fas induced apoptosis. It is recruited to Fas after the receptor cross-linking. Overexpression of wild type of FLASH facilitates and its dominant negative form inhibits Fas induced apoptosis. FLASH interacts with the DEDs of caspase-8 and FADD through the DED-like domain of FLASH and mediates activation of caspase-8 (1). There are parallels between FLASH and Apaf-1/CED-4 although there are arguments against their structural similarity (1,2). FLASH is widely expressed.Synonyms: CASP8-associated protein 2, KIAA1315, RIP25
    ID gène
    9994
    UniProt
    Q9Y563
    Pathways
    Chromatin Binding, Positive Regulation of Endopeptidase Activity
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