GFRA1 anticorps (Intermediate Domain)

N° du produit ABIN499883

L’anticorps anti-GFRA1 Polyclonal Lapin est utilisé pour la détection de GFRA1 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, IHC (p) et EIA.

Aperçu rapide pour GFRA1 anticorps (Intermediate Domain) (ABIN499883)

Antigène: GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GFRA1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-GFRA1 anticorps

Épitope: Intermediate Domain

Specificité: GFR alpha 1 antibody was raised against a peptide corresponding to amino acids 369 to 382 of human GFR alpha 1.

Purification: DEAE Chromatography

Immunogène: Human GFR alpha 1 (Intermediate Domain) Peptide

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur GFRA1

Antigène: GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))

Autre désignation: GFRA1 / GDNFR-alpha

Sujet: Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRa, which is a cell surface receptor for GDNF. The cDNAs encoding GDNFRalpha from human, rat, chicken and mouse have been cloned recently. GDNFRalpha was also termed Ret ligand 1 (RETL1) or TGF-beta-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRalpha-1 recently. GFRalpha-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFRalpha and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.Synonyms: GDNF family receptor alpha-1, GDNF receptor alpha, GDNFRA, GFR-alpha-1, RET ligand 1, RETL1, TGF-beta-related neurotrophic factor receptor 1, TRNR1

ID gène: 2674

UniProt: P56159