GFRA3
Reactivité: Humain
ELISA, WB
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
ELISA. Western Blot: 1/500 to 1/1000. Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Buffer
PBS containing 0.02 % sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C
Stockage commentaire
Store the antibody undiluted at 2-8 °C.
Antigène
GFRA3
(GDNF Family Receptor alpha 3 (GFRA3))
Autre désignation
GFRA3 / GDNFR-alpha 3
Sujet
Members of the glial cell line-derived neurotrophic factor (GDNF) family including GDNF and neurturin (NTN) play essential roles in the control of vertebrate neuron survival and differentiation. A new member of the GDNF family was recently identified and designated persephin. Physiological responses to these neurotrophic factors require two receptor subunits, the novel glycosylphosphadidylinositol linked protein GFRalpha and Ret receptor tyrosine kinase GFRbeta (2). Following the findings of GFR?-1 and -2, a novel receptor in GFRalpha family was identified very recently from human and mouse and designated GFRalpha-3. GFRalpha-3 binds persephin, thus, persephin, GFRalpha-3, and Ret PTK form a complex to transduce persephin signal and to mediate persephin function.Synonyms: GDNF family receptor alpha-3, GDNF receptor alpha-3, GFR-alpha-3