GPAM anticorps (C-Term)

N° du produit ABIN499910

L’anticorps Lapin Polyclonal anti-GPAM a été validé pour WB, IHC (p) et EIA. Il convient pour détecter GPAM dans des échantillons de Humain, Rat et Souris.

Aperçu rapide pour GPAM anticorps (C-Term) (ABIN499910)

Antigène: GPAM (Glycerol-3-Phosphate Acyltransferase, Mitochondrial (GPAM))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GPAM est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-GPAM anticorps

Épitope: C-Term

Specificité: This antibody reacts to GPAT1.

Purification: Affinity chromatography purified via peptide column

Immunogène: GPAT1 antibody was raised against a 15 amino acid peptide near the carboxy terminus of the human GPAT1.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur GPAM

Antigène: GPAM (Glycerol-3-Phosphate Acyltransferase, Mitochondrial (GPAM))

Autre désignation: GPAM / GPAT1

Sujet: Glycerol-3-phosphate acyltransferase 1 (GPAT1), one of four known GPAT isoforms, is located on the mitochondrial outer membrane, allowing reciprocal regulation with carnitine palmitoyltransferase-1. It is thought to be critical for the development of hepatic steatosis, steatosis triggered by GPAT1 overexpression leads to hepatic and possibly peripheral insulin resistance. GPAT1 is transcriptionally upregulated by insulin and sterol regulatory element binding protein (SREBP-1) and downregulated by AMP-activated protein kinase. Mice deficient in GPAT1 exhibit decreased triacylglycerol (TAG) in cardiomyocytes even in high-fat diets, suggesting that GPAT1 contributes significantly to TAG accumulation in heart tissue during lipogenic or high fat diets. At least two isoforms of GPAT1 are known to exist.Synonyms: Glycerol-3-phosphate acyltransferase 1, KIAA1560

ID gène: 57678

NCBI Accession: NP_065969

UniProt: Q9HCL2

Pathways: Activated T Cell Proliferation