GPR3 anticorps (C-Term)

N° du produit ABIN499914

Détail du produit anti-GPR3 anticorps

Antigène: GPR3 (G Protein-Coupled Receptor 3 (GPR3))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GPR3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to GPR3.

Purification: Affinity chromatography purified via peptide column

Immunogène: GPR3 antibody was raised against a 13 amino acid peptide from near the carboxy terminus of human GPR3.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur GPR3

Antigène: GPR3 (G Protein-Coupled Receptor 3 (GPR3))

Autre désignation: GPR3 / ACCA (GPR3 Produits)

Synonymes: anticorps GPR3, anticorps ACCA, anticorps Gpcr3, anticorps Gpcr20, anticorps Gpcr21, anticorps G protein-coupled receptor 3, anticorps G-protein coupled receptor 3, anticorps GPR3, anticorps Gpr3

Sujet: GPR3, also known as ACCA, is a G-protein coupled receptor that constitutively activates adenylate cyclase and is highly expressed in the central nervous system. Overexpression of GPR3 stimulates the production of amyloid-b peptide (Ab), the deposition of which is one of the pathological hallmarks of Alzheimer 's disease (AD), while the ablation of GPR3 prevented the accumulation of Ab in vitro and in an AD mouse model. This is of particular interest because of the proximity of a reported candidate Alzheimer 's disease (AD) locus, suggesting that GPR3 may be a potential therapeutic target for the treatment of AD. GPR3 has also been shown to block the proliferation of cerebellar granule cell precursors (GCP) during postnatal development by inhibiting the Shh-induced proliferation of GCP, indicating that GPR3 activation may represent one of the signals that triggers the postnatal cell cycle exit and terminal differentiation of GPCs.Synonyms: ACCA orphan receptor, G-protein coupled receptor 3

ID gène: 2827

UniProt: P46089

Pathways: cAMP Metabolic Process