HRK anticorps (Center)

N° du produit ABIN499950

Cet anticorps anti-HRK Polyclonal Lapin (ABIN499950) détecte spécifiquement HRK dans WB et EIA. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour HRK anticorps (Center) (ABIN499950)

Antigène: HRK (Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HRK est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-HRK anticorps

Épitope: Center

Specificité: This antibody recognizes HRK.

Purification: Peptide Affinity Chromatography

Immunogène: HRK antibody was raised against a 15 amino acid peptide from near the center of Human Hrk.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: 2.5-5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur HRK

Antigène: HRK (Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK))

Autre désignation: Harakiri / HRK

Sujet: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Hrk, a pro-apoptotic member of the Bcl-2 homology domain-3 (BH3)-only group of the Bcl-2 family of proteins, was also identified as novel protein induced during programmed neuronal death. It lacks significant homology to other Bcl-2 family members except for an 8-amino acid region that is similar to the BH3 motif of Bik. Hrk regulates apoptosis through interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL via this domain. It does not interact with the pro-apoptotic proteins Bax, Bak, or Bcl-XS. Hrk localizes to mitochondrial membranes in a pattern similar to that previously reported for Bcl-2 and Bcl-XL. Despite its predicted molecular weight, Hrk often migrates at 12-15 kDa.Synonyms: Activator of apoptosis harakiri, BH3-interacting domain-containing protein 3, BID3, Neuronal death protein DP5

ID gène: 8739

NCBI Accession: NP_003797

UniProt: O00198