ILP-2 anticorps

N° du produit ABIN500020

Cet anticorps Lapin Polyclonal détecte spécifiquement ILP-2 dans WB, IF et EIA. Il présente une réactivité envers Humain, Rat et Souris.

Aperçu rapide pour ILP-2 anticorps (ABIN500020)

Antigène: ILP-2 (BIRC8) (Baculoviral IAP Repeat-Containing 8 (BIRC8))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ILP-2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-ILP-2 anticorps

Specificité: ILP-2 antibody was raised with against a synthetic peptide corresponding to amino acids near the amino terminus of human ILP-2.

Purification: Affinity chromatography purified via peptide column

Immunogène: Human ILP-2 Peptide

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: 1 to 2 μg/mL. Human HepG2 or MOLT4 cell lysate can be used as a positivecontrol and a band at approximately 33 kDa can be detected. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur ILP-2

Antigène: ILP-2 (BIRC8) (Baculoviral IAP Repeat-Containing 8 (BIRC8))

Autre désignation: BIRC8 / ILP2

Sujet: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2 (1). ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues (1). ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.Synonyms: Baculoviral IAP repeat-containing protein 8, IAP-like protein 2, ILP-2, Inhibitor of apoptosis-like protein 2, Testis-specific inhibitor of apoptosis

ID gène: 112401

NCBI Accession: NP_203127

UniProt: Q96P09